p190A/ ARHGAP35 and p190B/ ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau · 2026
Read p190A/ ARHGAP35 and p190B/ ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay by Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13560762.txt.
Description
Two sister proteins that brake cell movement, p190A and p190B, keep turning up mutated in womb-lining cancer. Mathilde Pinault and eleven co-authors studied the pair in 2026, asking how losing one or both changes endometrial cancer cells.
In patient samples, the two genes were often mutated together and both were expressed less in tumors than in healthy tissue. The team knocked out each gene in a cancer cell line. Losing either one reshaped the cell's actin skeleton in the same way, through one signaling route, and protein profiling showed matching shifts. Losing both at once killed the cells, which the authors flag as a possible treatment opening.
Catalog record
| CREATOR | Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |