NNMT-associated metabolic–thromboinflammatory–immune co-activation in heterogeneous CTC clusters: a hypothesis-generating computational framework”
Jiayang Gong, Zhe Wang, Yun Shi, Minlan Ren, Tingting Li, Gang Li, Rui Peng · 2026
Read NNMT-associated metabolic–thromboinflammatory–immune co-activation in heterogeneous CTC clusters: a hypothesis-generating computational framework” by Jiayang Gong, Zhe Wang, Yun Shi, Minlan Ren, Tingting Li, Gang Li, Rui Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13560392.txt.
Description
Jiayang Gong and co-authors build a computational framework linking an enzyme to the protective crowds around traveling tumor cells in a 2026 paper. Clusters of circulating tumor cells survive the bloodstream by recruiting platelets, neutrophils, and immune cells as shields. The enzyme NNMT, tied to metabolic rewiring and immune suppression, might coordinate that shield.
With no new lab data, the team mined public sources: pan-cancer gene data plus eight single-cell data sets totaling nearly half a million cells. Scores for metabolism, clotting, neutrophil traps, and immune exhaustion rose together with NNMT levels. Machine learning could tell lone tumor cells from clustered ones using those features. The authors stress the work only generates hypotheses, offering a map for experiments to test.
Catalog record
| CREATOR | Jiayang Gong, Zhe Wang, Yun Shi, Minlan Ren, Tingting Li, Gang Li, Rui Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |