Risk factors and treatment strategies for live birth in women with high BMI undergoing ART
Yunhan Nie, Yuting Huang, Zhe Kuang, Mingru Yin, Xi Shen, Yali Liu, Hongyuan Gao, Hui Long, Li Wang · 2026
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Description
Yunhan Nie and colleagues sift a decade of fertility treatment records to learn why women with high body mass index repeatedly fail to reach live birth, and what might change the odds. Their 2026 retrospective cohort covers 10,581 women treated from 2010 to 2023, split into overweight and obese groups by Chinese cutoffs. Mixed models separated risk factors for repeated failure from strategies after a first failed transfer.
Women with recurrent failure were older and had poorer ovarian reserve than those who succeeded. Age stood confirmed as a key risk, roughly doubling the odds of repeat failure in the adjusted estimate. Higher stimulation drug doses per mature follicle also raised failure risk. Switching to a progestin-primed stimulation protocol after failure lowered the risk of failing again, as did transferring a blastocyst-stage embryo. The authors distinguish fixed risks from adjustable ones and suggest risk-stratified adjustments for lower-risk patients.
Catalog record
| CREATOR | Yunhan Nie, Yuting Huang, Zhe Kuang, Mingru Yin, Xi Shen, Yali Liu, Hongyuan Gao, Hui Long, Li Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 97038 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |