Clinical characteristics in antibody-positive pediatric patients with immune-mediated necrotizing myopathy
Yiwen Xu, Zhanwei Zhang, Yixuan Chu, Fang He, Leilei Mao, Li Yang, Fei Yin, Jing Peng, Lifen Yang, Ciliu Zhang · 2026
Read Clinical characteristics in antibody-positive pediatric patients with immune-mediated necrotizing myopathy by Yiwen Xu, Zhanwei Zhang, Yixuan Chu, Fang He, Leilei Mao, Li Yang, Fei Yin, Jing Peng, Lifen Yang, Ciliu Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560333.txt.
Description
Yiwen Xu and colleagues characterize childhood immune-mediated necrotizing myopathy in antibody-positive patients at a single Chinese center. Their 2026 retrospective study reviews ten children diagnosed between January 2016 and May 2025 at Xiangya Hospital. This rare autoimmune muscle disease destroys fibers faster than it inflames them, and pediatric evidence is scarce.
Every child showed symmetric weakness in the muscles nearest the trunk, and half had skin signs such as Gottron's papules or a rash around the eyes. Muscle enzyme levels ran dramatically high, with a median near four thousand units per liter in the reported figures. Six children carried anti-SRP antibodies and four carried anti-HMGCR. All received steroids plus methotrexate, most also got intravenous immunoglobulin, and half received rituximab. Outcomes were mixed: two complete remissions, several non-responses, and four relapses during follow-up.
Catalog record
| CREATOR | Yiwen Xu, Zhanwei Zhang, Yixuan Chu, Fang He, Leilei Mao, Li Yang, Fei Yin, Jing Peng, Lifen Yang, Ciliu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46299 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |