Reducing opioid exposure after cardiac surgery with parasternal intercostal plane blocks (EPOCH CardioLink-10)—authors' response
Ahmad Alli, C David Mazer, Subodh Verma, EPOCH CardioLink-10 Investigators · 2026
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Description
Ahmad Alli and co-authors reply in 2026 to notes on their trial of nerve blocks to cut opioid use after heart surgery. The trial ran at four Canadian centers and tested a tube-based block by the breastbone against a dummy drip. The critics had asked if a single shot might do as well as the tube plan.
The team says the trial was built to test the tube plan as used, not to split shot from drip effects. Their plan in fact gave small doses on a timer, not one steady flow. Opioid use at 72 hours fell by a clear sum, and high use was near halved, with pain held level. No grave block harms arose in 318 patients. One-center trials can puff up gains, they add.
Catalog record
| CREATOR | Ahmad Alli, C David Mazer, Subodh Verma, EPOCH CardioLink-10 Investigators |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |