Human primordial germ cell heterogeneity in vitro is associated with distinctive biological states
Young Sun Hwang, Qiu Ya Wu, Sissy E Wamaitha, Amander T Clark · 2026
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Description
Young Sun Hwang and three colleagues explore why lab-grown human primordial germ cell-like cells split into distinct states. Their 2026 study centers on DND1, a protein whose production from its message varies between cells. Dual fluorescent reporters, single-cell sequencing, and functional assays tracked what the DND1-positive state means for these early germline cells.
DND1-producing cells were rich in RNA regulation machinery, including genes tied to processing bodies and translation control. They divided slowly, exited the cell cycle, and raised the brake protein P27 in their nuclei. At the same time they kept stable expression of genes the germline needs for later differentiation. Adding the signal BMP2 steadied DND1 production without changing its message level or growth rate. The authors conclude that control after transcription coordinates cell cycle behavior with germ cell identity during development.
Catalog record
| CREATOR | Young Sun Hwang, Qiu Ya Wu, Sissy E Wamaitha, Amander T Clark |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 73602 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |