Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies
Siqi Xu, Jiming Guo, Ying Kang, Qinjing Wang, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia · 2026
Read Aging of hair follicle stem cells and their niche: mechanisms and regenerative therapeutic strategies by Siqi Xu, Jiming Guo, Ying Kang, Qinjing Wang, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560252.txt.
Description
Siqi Xu and colleagues review how hair follicle stem cells and their supporting niche age together, thinning hair and draining its color. Their 2026 article maps the follicle's growth cycle and the anatomical changes aging brings to the bulge where the stem cells live. Exhausted stem cells lose regenerative power just as their neighborhood degrades on several levels at once.
The review separates niche decay into tissue, cellular, and molecular layers, showing how each disturbs the balance between stem cell rest and activation. Therapeutic strategies under discussion range from niche repair to stem cell based restoration. The authors look ahead to pairing high-resolution spatial technologies with genomic data, hoping to watch aging unfold cell by cell in place and time. Their goal is a mechanistic framework firm enough to guide real hair regeneration treatments.
Catalog record
| CREATOR | Siqi Xu, Jiming Guo, Ying Kang, Qinjing Wang, Yue Ming, Weixing Chen, Min Wang, Zhijie Huang, Yisheng Huang, Bo Jia |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |