MicroRNA-345-3p expression inhibits colorectal cancer liver metastasis by targeting KHDRBS1 and TGF-β signaling pathway
Song Fan, Jian Zhao, Songjie Liu, Bing Xu, Xiangting Cheng · 2026
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Description
Fan and colleagues study a small control molecule, microRNA-345-3p, that appears to restrain colorectal cancer's spread to the liver, in 2026 cancer research. The team collected blood from 110 colorectal cancer patients and 90 healthy people, measuring the microRNA and a target gene. They then raised the molecule's levels in cancer cells in the lab to watch growth and the shape-shifting process, called epithelial-mesenchymal transition, that helps cancers invade new organs.
Patients whose cancer had reached the liver showed much lower microRNA-345-3p than other patients. Low levels tracked with advanced tumor stage, deeper invasion, lymph node spread, and poorer outlook. Restoring the molecule in cells slowed growth and reversed transition-linked changes. A gene named KHDRBS1 proved to be its target: restoring that gene canceled the microRNA's tumor-slowing effects, acting through the TGF-beta signaling pathway. Fan suggests the molecule as a marker of spread risk.
Catalog record
| CREATOR | Song Fan, Jian Zhao, Songjie Liu, Bing Xu, Xiangting Cheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |