Finerenone mitigates acute alcoholic myocardial injury by modulating inflammatory signaling, oxidative stress, and mitochondrial function
Ching-Han Liu, Tian-Huei Chu, Shih-Ming Yang, Yi-Chen Wang, Wen-Chin Lee, Yi-Chen Chang, Yao-Chang Chen, Yi-Jen Chen, Cheng-Chieh Fang, Zhi-Hong Wen, Chien-Wei Feng, Hao-Ming Wu, Po-Tseng Lee, Nan-Chieh Huang, Shih-Chung Huang · 2026
Read Finerenone mitigates acute alcoholic myocardial injury by modulating inflammatory signaling, oxidative stress, and mitochondrial function by Ching-Han Liu, Tian-Huei Chu, Shih-Ming Yang, Yi-Chen Wang, Wen-Chin Lee, Yi-Chen Chang, Yao-Chang Chen, Yi-Jen Chen, Cheng-Chieh Fang, Zhi-Hong Wen, Chien-Wei Feng, Hao-Ming Wu, Po-Tseng Lee, Nan-Chieh Huang, Shih-Chung Huang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560241.txt.
Description
Ching-Han Liu and colleagues test finerenone, a newer mineralocorticoid receptor blocker, against acute alcohol injury to the heart. Their 2026 study works in rat heart cells exposed to ethanol and in mice given three days of alcohol. No curative drug exists for alcoholic cardiomyopathy, and alcohol raises aldosterone, the hormone this drug class counters.
In cells, finerenone blunted ethanol's effects: fewer cells died, mitochondria stayed less fragmented, and inflammatory signaling quieted. The drug also curbed ethanol's upregulation of the mineralocorticoid receptor itself. In mice, it lowered the blood injury marker CK-MB and reduced heart cell death and tissue damage. Inflammation, oxidative stress, and mitochondrial dysfunction all eased with treatment. The authors propose finerenone as a protective candidate for acute alcoholic heart injury, while noting that clinical evidence must follow this preclinical work.
Catalog record
| CREATOR | Ching-Han Liu, Tian-Huei Chu, Shih-Ming Yang, Yi-Chen Wang, Wen-Chin Lee, Yi-Chen Chang, Yao-Chang Chen, Yi-Jen Chen, Cheng-Chieh Fang, Zhi-Hong Wen, Chien-Wei Feng, Hao-Ming Wu, Po-Tseng Lee, Nan-Chieh Huang, Shih-Chung Huang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53546 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |