A magnetic resonance imaging-guided drug delivery system for premetastatic niche theranostics and colorectal cancer liver metastasis intervention
Wangping Luo, Xiaoyan Yang, Yining Wang, Jianxia Xu, Yijie Lou, Jiayi Chen, Jue Hou, Xiaojie Wang, Yuanfei Lu, Jin Mao, Guping Tang, Hongzhen Bai, Risheng Yu · 2026
Read A magnetic resonance imaging-guided drug delivery system for premetastatic niche theranostics and colorectal cancer liver metastasis intervention by Wangping Luo, Xiaoyan Yang, Yining Wang, Jianxia Xu, Yijie Lou, Jiayi Chen, Jue Hou, Xiaojie Wang, Yuanfei Lu, Jin Mao, Guping Tang, Hongzhen Bai, Risheng Yu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560219.txt.
Description
Wangping Luo and colleagues engineer a nanoparticle system that both images and treats the premetastatic niche forming in the liver before colorectal cancer spreads there. Their 2026 study targets the crosstalk between activated hepatic stellate cells, which drive liver fibrosis, and incoming cancer cells. The particle core is mesoporous iron oxide loaded with curcumin, wrapped in cancer cell membrane for camouflage.
The coating displays a receptor that homes to signals secreted by activated stellate cells, while also recognizing fellow colorectal cancer cells. The iron core lights up on T2-weighted MRI, letting the team watch fibrosis and early metastatic foci. Curcumin dosing boosts the drug's natural power to break up the stellate-cancer crosstalk. Tests in fibrosis and liver metastasis models showed the system suppressing niche formation and slowing metastatic progression. The authors present it as a theranostic platform joining detection with intervention.
Catalog record
| CREATOR | Wangping Luo, Xiaoyan Yang, Yining Wang, Jianxia Xu, Yijie Lou, Jiayi Chen, Jue Hou, Xiaojie Wang, Yuanfei Lu, Jin Mao, Guping Tang, Hongzhen Bai, Risheng Yu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83218 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |