Biology-informed risk stratification of glioblastoma by integrating MRI-based intratumoral heterogeneity with clinical features: a multicenter validation study
Junfeng Zhang, Hong Guo, Xiaoxiao Ma, Yujue Zhong, Xiaojun Yu, Xiangbing Bian, Jianxing Hu, Caohui Duan, Yilong Huang, Jialing Wu, Mingliang Yang, Jian Hu, Xiaobo Zhang, Luhua Zhang, Rui Jiang, Xin Lou · 2026
Read Biology-informed risk stratification of glioblastoma by integrating MRI-based intratumoral heterogeneity with clinical features: a multicenter validation study by Junfeng Zhang, Hong Guo, Xiaoxiao Ma, Yujue Zhong, Xiaojun Yu, Xiangbing Bian, Jianxing Hu, Caohui Duan, Yilong Huang, Jialing Wu, Mingliang Yang, Jian Hu, Xiaobo Zhang, Luhua Zhang, Rui Jiang, Xin Lou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560186.txt.
Description
Junfeng Zhang and colleagues build a glioblastoma risk model from MRI measures of how varied the tumor's inner habitats look, blended with routine clinical features. Their 2026 multicenter study covers 836 patients with IDH-wildtype tumors from six centers, with records reaching back to 1996. A habitat risk score came from three-dimensional vascular habitat maps drawn on preoperative scans.
Four factors independently predicted survival: the habitat score, performance status, a methylation marker, and how much tumor surgeons removed. The combined radio-clinical model beat either part alone, with concordance of 0.74 and 0.77 in the spatial and temporal validation sets in the reported results. It split patients into risk groups under any first-line regimen. High-risk tumors showed more stemness and wider oxygen-starved regions, while low-risk tumors looked immune-stimulatory. A web platform delivers the score for bedside use.
Catalog record
| CREATOR | Junfeng Zhang, Hong Guo, Xiaoxiao Ma, Yujue Zhong, Xiaojun Yu, Xiangbing Bian, Jianxing Hu, Caohui Duan, Yilong Huang, Jialing Wu, Mingliang Yang, Jian Hu, Xiaobo Zhang, Luhua Zhang, Rui Jiang, Xin Lou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63556 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |