A ‘Tangled Web’ in the CNS: unraveling neutrophil extracellular traps in neurological disorders
Haixia Wang, Ruiming Wen, Emily Parker, Luodan Yang · 2026
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Description
Haixia Wang and three colleagues review neutrophil extracellular traps in diseases of the central nervous system. Their 2026 article explains these web-like structures of DNA, histones, and antimicrobial proteins that neutrophils cast out to snare pathogens. Helpful in infection, the traps turn harmful when they form excessively or clear too slowly inside the brain.
The review covers how neutrophils cross the blood-brain barrier, what triggers trap release there. The webs then contribute to stroke, traumatic brain injury, bleeding around the brain, Alzheimer's disease, and multiple sclerosis. Oxidative stress and inflammatory mediators feature among the triggers discussed. Emerging treatments aim either to stop traps forming or to dissolve them faster, and the authors survey that neuroprotective pipeline. They frame the synthesis as a guide for researchers hunting new targets in neurological disorders.
Catalog record
| CREATOR | Haixia Wang, Ruiming Wen, Emily Parker, Luodan Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104849 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |