Association between hemoglobin A1c to HDL cholesterol ratio and hypertension in middle-aged and older Chinese adults: a cross-sectional study
Wenqing Si, Weicheng Lai, Liangxiu Wu, Shenshen Du, Yupeng Wu, Xin Li, Wenlong Zhao, Liangyan Wu, Boda Zhou · 2026
Read Association between hemoglobin A1c to HDL cholesterol ratio and hypertension in middle-aged and older Chinese adults: a cross-sectional study by Wenqing Si, Weicheng Lai, Liangxiu Wu, Shenshen Du, Yupeng Wu, Xin Li, Wenlong Zhao, Liangyan Wu, Boda Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13560115.txt.
Description
Wenqing Si and colleagues test a combined blood index against hypertension among Chinese adults in midlife and beyond. Their 2026 cross-sectional study uses the 2011 and 2015 biomarker waves of a national aging survey, keeping 11,797 participants from an initial pool of 25,873. The index divides glycated hemoglobin by HDL cholesterol, joining chronic sugar exposure with lipid metabolism in one number.
Higher values tracked with higher odds of hypertension after full adjustment for social, lifestyle, and metabolic factors. People in the high group carried 38 percent higher odds than those in the low group in the adjusted comparison. Spline analysis showed the relationship bending rather than running straight, a nonlinear pattern. The authors caution that a cross-sectional snapshot shows association only, never cause or prediction. They call for prospective studies to test whether the index adds anything to standard risk assessment.
Catalog record
| CREATOR | Wenqing Si, Weicheng Lai, Liangxiu Wu, Shenshen Du, Yupeng Wu, Xin Li, Wenlong Zhao, Liangyan Wu, Boda Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40438 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |