Single-cell mapping of homocysteine-induced perturbations in avian embryogenesis using LMO and BD rhapsody transcriptomics
Stéphanie Maupetit-Méhouas, Felipe Maurelia, Pouria Hosseinnia, Nicolas Allègre, Yoan Renaud, Jonas Cruzel, Claire Chazaud, Charlène Guillot · 2026
Read Single-cell mapping of homocysteine-induced perturbations in avian embryogenesis using LMO and BD rhapsody transcriptomics by Stéphanie Maupetit-Méhouas, Felipe Maurelia, Pouria Hosseinnia, Nicolas Allègre, Yoan Renaud, Jonas Cruzel, Claire Chazaud, Charlène Guillot (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13560026.txt.
Description
Stéphanie Maupetit-Méhouas, Felipe Maurelia, Pouria Hosseinnia, and a wider team wrote this research paper, published in 2026. It reads single-cell gene activity in chick embryos to find how excess homocysteine, an amino acid linked to birth defects, disturbs early development.
Single-cell studies can drown faint effects in noise and processing quirks. The team tagged cells with lipid-linked barcodes and processed several treatment doses together on one platform, keeping conditions even. Comparing merged and unmerged analyses showed that merging kept broad cell types but could hide the very signals sought. The unmerged data revealed gene shifts in the progenitor cells that build the spine and body axis, matching defects in axis lengthening. The authors offer the workflow as a way to catch subtle treatment effects in non-standard model animals.
Catalog record
| CREATOR | Stéphanie Maupetit-Méhouas, Felipe Maurelia, Pouria Hosseinnia, Nicolas Allègre, Yoan Renaud, Jonas Cruzel, Claire Chazaud, Charlène Guillot |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |