OTUD5 maintains STAT1/2 stability and promotes IFNγ-driven intestinal inflammation
Huiyuan Guan, Changzhou Cai, Jiewei Wang, Zhaoxue Liu, Jin Peng, Xupeng Bai, Lingzhi Wu, Kun Jiang, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Zhe Shen · 2026
Read OTUD5 maintains STAT1/2 stability and promotes IFNγ-driven intestinal inflammation by Huiyuan Guan, Changzhou Cai, Jiewei Wang, Zhaoxue Liu, Jin Peng, Xupeng Bai, Lingzhi Wu, Kun Jiang, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Zhe Shen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13559827.txt.
Description
Inflammatory bowel disease is characterized by unresolved mucosal inflammation driven mainly by TNFα and/or interferon gamma (IFNγ). While anti-TNFα biologics are a clinical mainstay, therapeutic resistance remains a significant hurdle. The molecular mechanisms that sustain inflammation in anti-TNFα nonresponders are not fully understood.
Catalog record
| CREATOR | Huiyuan Guan, Changzhou Cai, Jiewei Wang, Zhaoxue Liu, Jin Peng, Xupeng Bai, Lingzhi Wu, Kun Jiang, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Zhe Shen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |