Metabolic Dysfunction–Associated Steatotic Liver Disease Is Associated With Adverse Social Factors: An Analysis Using All ofUs
Manuela Araque, Stephanie M. Garces, Hui Yu, Mengsheng Zha, Sakina Qazi, Yan Guo, David Goldberg, Vatche Agopian, Jacob L. McCauley, Yvonne N. Flores, Patricia D. Jones · 2026
Read Metabolic Dysfunction–Associated Steatotic Liver Disease Is Associated With Adverse Social Factors: An Analysis Using All ofUs by Manuela Araque, Stephanie M. Garces, Hui Yu, Mengsheng Zha, Sakina Qazi, Yan Guo, David Goldberg, Vatche Agopian, Jacob L. McCauley, Yvonne N. Flores, Patricia D. Jones (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13559805.txt.
Description
Manuela Araque and colleagues examine how social conditions track with metabolic dysfunction-associated steatotic liver disease in the All of Us research database. Their 2026 cross-sectional analysis identified cases by diagnosis codes, excluded other liver diseases and heavy alcohol use, then matched cases to controls by age and race or ethnicity. The matched sample held 57,895 participants, with full survey data for 16,666.
People with the liver disease were more likely to report incomes at or below $35,000 and schooling below high school level. They also scored higher on social isolation, neighborhood disorder, perceived stress, food insecurity, and transportation insecurity, each gap statistically significant. The authors note the disease already affects roughly a third of the world's adults by current estimates. They call for research on how these social factors combine to drive risk and progression, rather than treating each factor in isolation.
Catalog record
| CREATOR | Manuela Araque, Stephanie M. Garces, Hui Yu, Mengsheng Zha, Sakina Qazi, Yan Guo, David Goldberg, Vatche Agopian, Jacob L. McCauley, Yvonne N. Flores, Patricia D. Jones |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |