Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares · 2026
Read Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells by Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13559774.txt.
Description
Asensio-Juarez and co-authors study in 2026 how the cancer drug paclitaxel makes cancer cells contract, through cross talk between microtubules and the actomyosin system. Taxane drugs target microtubules in solid tumors, but the contraction path was not fully mapped. They traced the signal step by step.
The drug frees a factor called GEF-H1 from microtubules fast, which switches on the RhoA and ROCK path and activates the NM2 motor. Mutating one tubulin site slowed that release sharply, so the site gates the process. Blocking a tubulin modifying enzyme also delayed release. One enzyme's loss raised motor activity, which shows acetyl marks help hold contractile balance.
Catalog record
| CREATOR | Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |