Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy
Sinuo Sun, Suwei Zuo, Yanmeng Zhou, Jiayin Song, Yuanyuan Wang, Shibo Liu, Gang Xue, Xu Lin, Jingfang Wu · 2026
Read Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy by Sinuo Sun, Suwei Zuo, Yanmeng Zhou, Jiayin Song, Yuanyuan Wang, Shibo Liu, Gang Xue, Xu Lin, Jingfang Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13559676.txt.
Description
Sinuo Sun and colleagues study apolipoprotein E in papillary thyroid carcinoma, asking whether the protein pushes the cancer forward by switching on mitophagy, the cell's recycling of worn mitochondria. Their 2026 work combines cancer atlas and GEO dataset analysis with tissue staining, cell experiments, and a mouse xenograft model. APOE had already been tied to progression in this cancer, but the mechanism was missing.
APOE ran high in tumor tissue and cell lines. Raising it made cells proliferate more and die less, while lowering it flipped both effects. Extra APOE also activated the PINK1 and Parkin pathway that tags mitochondria for disposal, shifted energy-sensing signals, and increased autophagosome formation. Blocking mitophagy with drugs blunted the growth advantage, tying the behavior to the recycling pathway. Tumors in mice echoed the pattern. The authors suggest the APOE mitophagy axis as a lead for future preclinical work.
Catalog record
| CREATOR | Sinuo Sun, Suwei Zuo, Yanmeng Zhou, Jiayin Song, Yuanyuan Wang, Shibo Liu, Gang Xue, Xu Lin, Jingfang Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58903 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |