Association between the systemic immune-inflammation index and overall survival in patients with leukemia: a multicenter cohort study
Yiyang Chen, Muchen Ren, Sihui Liu, Tianyi Wang, Heyang Zhang, Junju He, Hanping Shi · 2026
Read Association between the systemic immune-inflammation index and overall survival in patients with leukemia: a multicenter cohort study by Yiyang Chen, Muchen Ren, Sihui Liu, Tianyi Wang, Heyang Zhang, Junju He, Hanping Shi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13559576.txt.
Description
Chen and co-authors test a routine inflammation score as a survival marker in leukaemia, and find the opposite of the usual pattern. Their 2026 multicentre study analyses 609 patients, calculating the systemic immune-inflammation index from platelets, neutrophils, and lymphocytes before treatment. In solid tumours, higher values predict worse survival, but leukaemia distorts blood counts through marrow failure, so the meaning was unclear.
A threshold derived from the training cohort split survival sharply. Patients above it had less than half the death hazard of those below after adjustment, and curve analyses suggested a nonlinear inverse relationship. A prediction nomogram built on the model calibrated acceptably in both cohorts. The authors suggest a higher index may signal lower disease burden and better-preserved blood production in leukaemia, reversing the marker's usual interpretation.
Catalog record
| CREATOR | Yiyang Chen, Muchen Ren, Sihui Liu, Tianyi Wang, Heyang Zhang, Junju He, Hanping Shi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |