CEBPG demonstrates oncogene functions and modulates the expression of genes involved in cervical cancer related pathways
Tingting Qi, Jing Yang, Guzhalinuer Abulizi · 2026
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Description
Tingting Qi, Jing Yang, and Guzhalinuer Abulizi investigate CEBPG, a transcription factor suspected of acting as an oncogene in cervical cancer. Their 2026 study first reads the factor's levels in cancer atlas data, then forces extra CEBPG into HeLa cervical cancer cells and watches the consequences. Gene sequencing after the change maps which genes the factor controls.
CEBPG ran markedly higher in cervical tumors than in normal tissue. Cells given extra amounts multiplied faster, migrated and invaded more readily, and resisted programmed cell death. Sequencing revealed many shifted genes concentrated in pathways for blood vessel growth, proliferation, and movement. The analysis nominated 27 likely direct target genes, several already tied to poor prognosis in this cancer. The authors frame CEBPG as a driver of malignant behavior and a candidate biomarker. Their functional evidence, though, comes from a single cell line.
Catalog record
| CREATOR | Tingting Qi, Jing Yang, Guzhalinuer Abulizi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |