STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma
Xiaoxue Chen, Wenjing Li, Yiyao Liu, Lei Zhang, Zhigang Zhao, Yue Wang, Linli Tian · 2026
Read STC1 is associated with tumor progression and suppressive niches in laryngeal squamous cell carcinoma by Xiaoxue Chen, Wenjing Li, Yiyao Liu, Lei Zhang, Zhigang Zhao, Yue Wang, Linli Tian (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13559559.txt.
Description
Xiaoxue Chen and colleagues explore the role of stanniocalcin-1, a protein called STC1, in laryngeal squamous cell carcinoma, a throat cancer prone to recurrence and treatment resistance. Their 2026 analysis works from public data, combining bulk and single-cell gene sequencing with clinical records. They probe where STC1 appears, what it correlates with, and how it relates to the tumor's immune surroundings.
High STC1 tracked with cancer spread, later stage, and shorter survival in the datasets examined. It also aligned with gene programs for tissue remodeling and a cell-state shift linked to invasion. Tumors rich in STC1 showed a suppressive immune setting, with fewer killer T cells and more resting macrophages. Single-cell data placed STC1 chiefly in epithelial cells, which signaled heavily to T cells through calming pathways. The authors suggest that targeting STC1 might loosen immune suppression, a hypothesis their computational study raises rather than tests.
Catalog record
| CREATOR | Xiaoxue Chen, Wenjing Li, Yiyao Liu, Lei Zhang, Zhigang Zhao, Yue Wang, Linli Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36227 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |