Natural History of Recurrent Acute Pancreatitis: Implications for Interventional Trial Design
Søren S Olesen, Niels Henrik Bruun, Line Davidsen, Srdan Novovic, Stig B Laursen, Enrique de‐Madaria, Dhiraj Yadav, Asbjørn M Drewes · 2026
Read Natural History of Recurrent Acute Pancreatitis: Implications for Interventional Trial Design by Søren S Olesen, Niels Henrik Bruun, Line Davidsen, Srdan Novovic, Stig B Laursen, Enrique de‐Madaria, Dhiraj Yadav, Asbjørn M Drewes (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13559513.txt.
Description
Søren S Olesen and colleagues chart the natural course of recurrent acute pancreatitis using Danish national registries. Their 2026 cohort study included 45,338 adults hospitalized with a first pancreatitis episode between 2000 and 2022. Recurrence meant a new hospital episode at least ninety days after the previous one. The team modeled how risk changes as episodes pile up.
Nearly seven thousand patients, 15.2 percent of the cohort, went on to recurrent disease during a median follow-up of 4.5 years. The twelve-month risk of yet another attack climbed from 17 percent after one recurrence to 46 percent after five. Gaps between episodes shortened as their number grew, a wear-out pattern the statistical models confirmed. Most returns happened within a year. The authors suggest that prevention trials will recruit most efficiently by targeting patients who already carry several episodes, since their near-term risk is highest.
Catalog record
| CREATOR | Søren S Olesen, Niels Henrik Bruun, Line Davidsen, Srdan Novovic, Stig B Laursen, Enrique de‐Madaria, Dhiraj Yadav, Asbjørn M Drewes |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43150 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |