Identification of Critical Genes for Recurrent Aphthous Ulcer by Transcriptome Data Analysis and Mendelian Randomization
Xingguo Fu, Haishan Zhang, Yaomei Li, Andi Li, Qiulin Liu, Xiaojuan Zeng · 2026
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Description
Xingguo Fu and co-authors hunt for key genes behind recurring mouth ulcers, in a 2026 study. These painful sores return again and again, and their cause is poorly understood. The team mined gene activity data from past studies of the condition. They then used a genetics method that tests whether gene activity itself helps cause the sores.
The first pass found one hundred eighty-four genes with changed activity. The genetics pass flagged a few hundred more, and the overlap left seven key genes. Five of them looked protective, while two raised risk. The seven cluster around cell movement, immune response, and metabolism control. The authors say these genes could seed new markers and drug ideas for a common, nagging condition.
Catalog record
| CREATOR | Xingguo Fu, Haishan Zhang, Yaomei Li, Andi Li, Qiulin Liu, Xiaojuan Zeng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |