The Role of Arp2/3 in End‐Resection During DNA Double‐Strand Break Repair
Felix Y. Zhou, James E. Haber · 2026
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Description
Felix Zhou and James Haber review a cell crew that aids DNA break repair in a 2026 paper. Cells fix double-strand breaks by copy from a twin strand, a path called homologous recombination. The fix starts with end resection, a chew-back of the break ends. Broken ends also roam more, which helps them find the twin. The crew under review, Arp2/3, builds actin nets that push that roam.
Work in budding yeast shows the crew is due to start and to keep long resection. Block resection, and the roam stops too. The tie is direct, the authors say. Yet more roam does not lift the fix rate in yeast tests. The crew works with kin parts: a WASP kin and myosin motors. The review maps the new yeast facts and asks what they mean for flies and mammals.
Catalog record
| CREATOR | Felix Y. Zhou, James E. Haber |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |