Gram-negative aetiology in hip and knee prosthetic joint infections: risk factors and implications for empirical antibiotic therapy—a retrospective cohort study
Sara Tedeschi, Marta Fernandez-Sampedro, Eleonora Zamparini, Nicolò Rossi, Giuseppe Ferraro, Alberto Pecorelli, Giacomo Fornaro, Maria Pia Neri, Cesare Faldini, Stefano Zaffagnini, Massimiliano De Paolis, Alessandra Maso, Simone Ambretti, Maddalena Giannella, Pierluigi Viale · 2026
Read Gram-negative aetiology in hip and knee prosthetic joint infections: risk factors and implications for empirical antibiotic therapy—a retrospective cohort study by Sara Tedeschi, Marta Fernandez-Sampedro, Eleonora Zamparini, Nicolò Rossi, Giuseppe Ferraro, Alberto Pecorelli, Giacomo Fornaro, Maria Pia Neri, Cesare Faldini, Stefano Zaffagnini, Massimiliano De Paolis, Alessandra Maso, Simone Ambretti, Maddalena Giannella, Pierluigi Viale (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13559185.txt.
Description
Infections around artificial hip and knee joints are usually treated at once with wide-cover antibiotics while cultures grow, but blanket cover for Gram-negative bacteria carries costs and risks. Sara Tedeschi and co-authors review 281 hip and knee joint infections treated surgically from 2015 to 2019, asking which features point to a Gram-negative cause.
Such bacteria caused 18 percent of cases, most often from the Enterobacterales group. Statistical analysis found hip infections carried nearly triple the odds of a Gram-negative cause, while infections appearing late after surgery carried about half the odds. Overall, a fifth of treatments failed. The authors argue these two simple clues can help doctors aim early antibiotic cover more precisely. The study appears in 2026.
Catalog record
| CREATOR | Sara Tedeschi, Marta Fernandez-Sampedro, Eleonora Zamparini, Nicolò Rossi, Giuseppe Ferraro, Alberto Pecorelli, Giacomo Fornaro, Maria Pia Neri, Cesare Faldini, Stefano Zaffagnini, Massimiliano De Paolis, Alessandra Maso, Simone Ambretti, Maddalena Giannella, Pierluigi Viale |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |