Endoplasmic reticulum stress-mediated disruption of mitochondrial homeostasis drives airway epithelial barrier fragility and enhances susceptibility to recurrent respiratory tract infections in children
Xiaoyi Chang, Wei Jing, Qingbin Liu, Xueli Wu · 2026
Read Endoplasmic reticulum stress-mediated disruption of mitochondrial homeostasis drives airway epithelial barrier fragility and enhances susceptibility to recurrent respiratory tract infections in children by Xiaoyi Chang, Wei Jing, Qingbin Liu, Xueli Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13559128.txt.
Description
Children who catch chest infections again and again may have fragile airway linings, and stress inside the lining cells could be the root. Xiaoyi Chang and co-authors investigated that root in this 2026 study. The stress sits in the cell protein-folding workshop and spills over to the cell power plants.
When the power plants falter, the lining loses its tight seal and germs slip through more easily. The team traced that chain in pediatric airway samples and models. Recurrent infections are among the most common childhood health problems and drive heavy clinic and hospital use. A mechanism that runs from cell stress to barrier failure suggests new treatment angles beyond antibiotics, such as calming the cell stress itself.
Catalog record
| CREATOR | Xiaoyi Chang, Wei Jing, Qingbin Liu, Xueli Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |