Dopaminergic‐ and Cholinergic‐Related Structural MRI Patterns Across Cognitive Subtypes of Parkinson's Disease With Mild Cognitive Impairment
Xueqin Bai, Haoxin Chen, Qiuyue Li, Shiwei Zhang, Shuangli Chen, Andan Qian, Ronghui Zhou, Yitong Cheng, Chenglong Xie, Zhen Wang, Yunjun Yang, Meihao Wang · 2026
Read Dopaminergic‐ and Cholinergic‐Related Structural MRI Patterns Across Cognitive Subtypes of Parkinson's Disease With Mild Cognitive Impairment by Xueqin Bai, Haoxin Chen, Qiuyue Li, Shiwei Zhang, Shuangli Chen, Andan Qian, Ronghui Zhou, Yitong Cheng, Chenglong Xie, Zhen Wang, Yunjun Yang, Meihao Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13558829.txt.
Description
Xueqin Bai and co-authors map brain patterns across thinking subtypes in Parkinson disease in a 2026 study. People with Parkinson disease and mild thinking problems fall into patterns tied to two brain chemical systems. One pattern centers on planning circuits, the other on the back of the brain, with different dementia risks.
Scans covered nearly two hundred patients and healthy controls. Patients were grouped by test profiles into normal, two single pattern, and mixed groups. Distinct shrinkage patterns appeared in deep brain nuclei and the basal forebrain. The posterior pattern showed marked loss in one cholinergic nucleus, matching its chemical link.
Catalog record
| CREATOR | Xueqin Bai, Haoxin Chen, Qiuyue Li, Shiwei Zhang, Shuangli Chen, Andan Qian, Ronghui Zhou, Yitong Cheng, Chenglong Xie, Zhen Wang, Yunjun Yang, Meihao Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |