Regenerative repair is connected to early and specific structural, immune, and metabolic MSC signatures in adult mammals
Miguel Thomas, Anastasia Pacary, Emmanuelle Arnaud, David Bernard, Cathy Maugis-Rabusseau, Christophe Guissard, Adèle Arlat, Noélie Davezac, Anne Lorsignol, Jenny Paupert, Elsa Gratianne Guillot, Arnaud Bonnaffoux, Béatrice Cousin, Valérie Planat-Benard, Paul Monsarrat, Louis Casteilla, Marielle Ousset · 2026
Read Regenerative repair is connected to early and specific structural, immune, and metabolic MSC signatures in adult mammals by Miguel Thomas, Anastasia Pacary, Emmanuelle Arnaud, David Bernard, Cathy Maugis-Rabusseau, Christophe Guissard, Adèle Arlat, Noélie Davezac, Anne Lorsignol, Jenny Paupert, Elsa Gratianne Guillot, Arnaud Bonnaffoux, Béatrice Cousin, Valérie Planat-Benard, Paul Monsarrat, Louis Casteilla, Marielle Ousset (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13558711.txt.
Description
Miguel Thomas and colleagues used single-cell sequencing in 2026 to ask why some injuries in adult mammals regenerate while most simply scar. Mesenchymal stem and stromal cells tend the repair in every tissue, and the team suspected that early shifts in their variety decide the outcome. Their mouse model stages regenerative and non-regenerative repair side by side in genetically identical adults, letting the early cell states be compared cleanly.
Distinct clusters of these stromal cells marked the two repair paths from the start. Unsupervised analysis organised their jobs into three coordinated functions: shaping tissue structure, steering inflammation and immunity, and managing metabolism. The authors bundle the trio into a framework they call SIM and argue that repair succeeds when the three act as one tissue-level response. The work reframes regenerative medicine around coaching cell states early, before scar programmes lock in.
Catalog record
| CREATOR | Miguel Thomas, Anastasia Pacary, Emmanuelle Arnaud, David Bernard, Cathy Maugis-Rabusseau, Christophe Guissard, Adèle Arlat, Noélie Davezac, Anne Lorsignol, Jenny Paupert, Elsa Gratianne Guillot, Arnaud Bonnaffoux, Béatrice Cousin, Valérie Planat-Benard, Paul Monsarrat, Louis Casteilla, Marielle Ousset |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48298 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |