Clinical benefit of palbociclib retreatment after abemaciclib exposure in hormone receptor positive, HER2 negative metastatic breast cancer
Muhan Yu, Michiko Yamashita, Mamoru Takada, Daisuke Takabatake, Mina Takahashi, Mariko Kochi, Maya Uno, Midori Kondo, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Ryotaro Teranaka, Kenjiro Aogi, Masayuki Otsuka · 2026
Read Clinical benefit of palbociclib retreatment after abemaciclib exposure in hormone receptor positive, HER2 negative metastatic breast cancer by Muhan Yu, Michiko Yamashita, Mamoru Takada, Daisuke Takabatake, Mina Takahashi, Mariko Kochi, Maya Uno, Midori Kondo, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Ryotaro Teranaka, Kenjiro Aogi, Masayuki Otsuka (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13558631.txt.
Description
Muhan Yu and thirteen colleagues reviewed in 2026 what happens when patients with metastatic breast cancer receive a second course of the cell-cycle drugs known as CDK4/6 inhibitors. These pills, paired with hormone therapy, are standard first treatment for hormone-sensitive, HER2-negative disease, yet progression and side effects force changes, and retreatment value was unproven. Records from two institutions covered 78 patients treated between 2018 and 2025 in three switching patterns.
Switching from one drug, abemaciclib, to another, palbociclib, gave the longest median time before treatment failed. Nearly two thirds of that group stayed on the second drug longer than on the first. Patients whose first course ended over side effects fared better than those whose cancer had progressed, while spread to internal organs predicted a poor retrial. The authors back selective retreatment and call for prospective trials.
Catalog record
| CREATOR | Muhan Yu, Michiko Yamashita, Mamoru Takada, Daisuke Takabatake, Mina Takahashi, Mariko Kochi, Maya Uno, Midori Kondo, Takeshi Nagashima, Hiroshi Fujimoto, Junta Sakakibara, Ryotaro Teranaka, Kenjiro Aogi, Masayuki Otsuka |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45102 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |