PKPD-Based Translational Modeling of Calaspargase Pegol Preclinical Activity in Hepatocellular Carcinoma
Eef Hoeben, Vincent Madelain, Chayan Acharya, Pierre Barbier Saint Hilaire, Ethika Tyagi, Malek Okour, Sylvain Fouliard · 2026
Read PKPD-Based Translational Modeling of Calaspargase Pegol Preclinical Activity in Hepatocellular Carcinoma by Eef Hoeben, Vincent Madelain, Chayan Acharya, Pierre Barbier Saint Hilaire, Ethika Tyagi, Malek Okour, Sylvain Fouliard (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13558373.txt.
Description
Eef Hoeben and co-authors modeled a leukemia drug for liver cancer in a 2026 study. The drug is a long-acting form of an enzyme that starves cells of a key food building block. It is approved as part of care for a blood cancer of the young, but its worth for solid tumors is far less explored.
Fresh reports hint the enzyme may also work on liver cancer, a hard and fast-growing tumor. The team built a math model that links drug dose to drug action, tuned on lab and animal data. Such a model can forecast how the drug might act in people. It helps pick doses and schedules for first trials in liver cancer.
Catalog record
| CREATOR | Eef Hoeben, Vincent Madelain, Chayan Acharya, Pierre Barbier Saint Hilaire, Ethika Tyagi, Malek Okour, Sylvain Fouliard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |