The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis
Yuanting Yang, Xuying Zhu, Yan Fang, Jialin Li, Xinghua Shao, Shu Li, Haijiao Jin, Chaojun Qi, Zhenyuan Li, Leyi Gu, Shan Mou, Qisheng Lin, Zhaohui Ni · 2026
Read The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis by Yuanting Yang, Xuying Zhu, Yan Fang, Jialin Li, Xinghua Shao, Shu Li, Haijiao Jin, Chaojun Qi, Zhenyuan Li, Leyi Gu, Shan Mou, Qisheng Lin, Zhaohui Ni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13557588.txt.
Description
Yuanting Yang and a large team of co-authors identify a protein that shields the kidney from a common injury, in this 2026 study. Acute kidney injury strikes over half of intensive care patients, and one driver is ferroptosis, a form of cell death fed by iron and fat oxidation. A process called lipophagy, in which cells digest their own fat droplets, seems to feed that death pathway.
Using single-cell analysis, the team pinpointed the regulator ESRRA in the kidney's proximal tubule cells. Mice lacking it in those cells fared worse, showing ESRRA protects by holding back the lipophagy pathway through a protein named RAB7. Gene-binding tests found ESRRA switches on a second gene, PIK3CA, whose signaling through the AKT-MTOR pathway suppresses the fat-digesting step. Blocking that chain let injury advance. The authors present the ESRRA pathway as a target for protecting kidneys.
Catalog record
| CREATOR | Yuanting Yang, Xuying Zhu, Yan Fang, Jialin Li, Xinghua Shao, Shu Li, Haijiao Jin, Chaojun Qi, Zhenyuan Li, Leyi Gu, Shan Mou, Qisheng Lin, Zhaohui Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |