Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs
Wenran Qiu, Hirotaka Nagai, Kohei Ota, Midori Nagai, Tomoyuki Furuyashiki · 2026
Read Chronic social defeat stress induces a hypoglycemic shift and depression-related behaviors, both prevented by antidiabetic drugs by Wenran Qiu, Hirotaka Nagai, Kohei Ota, Midori Nagai, Tomoyuki Furuyashiki (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13557117.txt.
Description
Wenran Qiu and co-authors show that long-term social stress in mice shifts blood sugar downward and brings on depression-like behavior, and that diabetes drugs can block both changes. Stress-linked mental illness is known to go with altered sugar control, but the direction and cause of the link were unclear.
The team used a model in which mice are repeatedly defeated by stronger mice. They compared strains that differ in how hard stress hits them, measuring blood sugar, hormones, and immune signals. Stressed mice avoided others, lost interest in rewards, and showed weaker thinking. Two diabetes drugs, given to one strain, prevented the sugar shift and the behavior changes. The work ties mood and metabolism more tightly.
Catalog record
| CREATOR | Wenran Qiu, Hirotaka Nagai, Kohei Ota, Midori Nagai, Tomoyuki Furuyashiki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |