Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
DeNard V. Simmons, Oscar Andrés Moreno-Ramos, Divya D. A. Raj, Konstantin Kaganovsky, Arin Pamukcu, Nora Vrieler, Tatiana Tkatch, Zhong Xie, Ana Isabel Silva de Sousa, Enrico Zampese, Jun Ding, Rajeshwar Awatramani, Charles J. Wilson, D. James Surmeier · 2026
Read Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra by DeNard V. Simmons, Oscar Andrés Moreno-Ramos, Divya D. A. Raj, Konstantin Kaganovsky, Arin Pamukcu, Nora Vrieler, Tatiana Tkatch, Zhong Xie, Ana Isabel Silva de Sousa, Enrico Zampese, Jun Ding, Rajeshwar Awatramani, Charles J. Wilson, D. James Surmeier (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13557058.txt.
Description
DeNard Simmons and co-authors report, in a 2026 study, an unexpected route by which dopamine calms a key output hub of the brain. The substantia nigra's output part is tied to the motor troubles of Parkinson's disease. Dopamine's grip on its neurons was only partly mapped.
Working in mouse brain slices, the team found dopamine receptors doing two jobs. They cut the sharp bursts of the calming signal GABA. They also suppressed a steady background form of that inhibition. Star-shaped support cells, astrocytes, largely carried the steady effect, the title reports. A transporter-dependent release from dopamine neurons themselves fed it. The circuitry explains how dopamine loss might unbalance movement control.
Catalog record
| CREATOR | DeNard V. Simmons, Oscar Andrés Moreno-Ramos, Divya D. A. Raj, Konstantin Kaganovsky, Arin Pamukcu, Nora Vrieler, Tatiana Tkatch, Zhong Xie, Ana Isabel Silva de Sousa, Enrico Zampese, Jun Ding, Rajeshwar Awatramani, Charles J. Wilson, D. James Surmeier |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |