618. Modulation of hippocampal fear engrams reveals circuit mechanisms linking maladaptive fear, memory deficits, and depressive-like behaviour
L P Iglesias, M C van den Oever, G Wegener, S Joca · 2026
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Description
L P Iglesias and co-authors probe fear memory cells in the hippocampus in 2026. Nine-week-old male mice took part. Fear learning was set at low or high shock levels.
Classic stress disorder symptoms tie to fear that spreads and will not fade. Mood and memory symptoms are less understood. The team labeled the cell groups active during learning. A designer receptor then let them quiet those cells later. Behavior tests tracked fear, memory, and depression-like signs. Readers see how one memory trace in the brain may link three kinds of symptoms at once.
Catalog record
| CREATOR | L P Iglesias, M C van den Oever, G Wegener, S Joca |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |