208. GABRA5 rs35399885 single nucleotide polymorphism is significantly associated with sensory hypoesthesia and pain sensitivity
A Enomoto, S Ohka, D Nishizawa, Y Ogai, S Kasai, S Ide, J Hasegawa, K Nakayama, M Hayashida, N Matsuura, T Ichinohe, K Fukuda, K Ikeda · 2026
Read 208. GABRA5 rs35399885 single nucleotide polymorphism is significantly associated with sensory hypoesthesia and pain sensitivity by A Enomoto, S Ohka, D Nishizawa, Y Ogai, S Kasai, S Ide, J Hasegawa, K Nakayama, M Hayashida, N Matsuura, T Ichinohe, K Fukuda, K Ikeda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556781.txt.
Description
Enomoto and co-authors tested whether a variant in the GABRA5 gene is linked to reduced touch sensation and to pain sensitivity in people. The gene codes for part of a receptor that calms nerve signaling. Animal work has tied it to chronic pain. The team studied two groups. One held 303 dental surgery patients, some of whom developed numbness after jaw surgery. The other held 500 healthy volunteers whose pain thresholds were measured with pressure.
Among men in the surgery group, the variant was strongly linked to developing numbness after surgery. No such link appeared in women. A similar pattern showed in the healthy men's pain thresholds. The authors conclude that this gene variant may mark higher risk of numbness and altered pain response in men. They present the work as the first human report linking this gene to pain.
Catalog record
| CREATOR | A Enomoto, S Ohka, D Nishizawa, Y Ogai, S Kasai, S Ide, J Hasegawa, K Nakayama, M Hayashida, N Matsuura, T Ichinohe, K Fukuda, K Ikeda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |