506. The transition to psychopathology: repeat mGluR5 PET scans in high-risk volunteers
M Nikolic, M Iqbal, N Palacio, C Caswell, S Cox, J Séguin, G Masserweh, F Vitaro, M Brendgen, S Parent, M Boivin, S Côté, R Tremblay, N Castellanos-Ryan, M Leyton · 2026
Read 506. The transition to psychopathology: repeat mGluR5 PET scans in high-risk volunteers by M Nikolic, M Iqbal, N Palacio, C Caswell, S Cox, J Séguin, G Masserweh, F Vitaro, M Brendgen, S Parent, M Boivin, S Côté, R Tremblay, N Castellanos-Ryan, M Leyton (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556753.txt.
Description
Nikolic and co-authors scanned the brains of young adults in 2026 before and after some fell ill, to track a receptor tied to brain change. The receptor helps the brain adapt to new settings, and its levels shift in drug and stress ills, though past reads clash. The team ran PET scans with a tagged ligand at ages eighteen and twenty-five in a long-followed youth group. Some had since grown mood, anxiety, or drug ills.
Receptor levels fell over the seven years in both the ill and the well groups. The fall ran steeper in those who fell ill. Tobacco users held lower levels than non-users across the brain. Past drug use was tested as a go-between for teen volatility and adult levels as well.
Catalog record
| CREATOR | M Nikolic, M Iqbal, N Palacio, C Caswell, S Cox, J Séguin, G Masserweh, F Vitaro, M Brendgen, S Parent, M Boivin, S Côté, R Tremblay, N Castellanos-Ryan, M Leyton |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |