188. A single high-dose acute injection of 5-MeO-DMT reverses stress-induced anhedonia in rats
S Socolow, B Richardson, S Nasini, M Lopez-Canul, V Bruno, G Gobbi · 2026
Read 188. A single high-dose acute injection of 5-MeO-DMT reverses stress-induced anhedonia in rats by S Socolow, B Richardson, S Nasini, M Lopez-Canul, V Bruno, G Gobbi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556727.txt.
Description
S Socolow and co-authors test a single high dose of 5-MeO-DMT in stressed rats in 2026. Rats went through thirty days of chronic mild stress. That routine produces loss of pleasure, a core sign of depression.
Loss of pleasure was measured with a sucrose preference test. A forced swim test measured giving-up behavior. One injection of the drug was then given. The team asked whether pleasure returned after that single dose. Few fast compounds have been tested against long stress routines. Readers see animal evidence on speed and strength of effect for a short-acting psychedelic.
Catalog record
| CREATOR | S Socolow, B Richardson, S Nasini, M Lopez-Canul, V Bruno, G Gobbi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |