434. The effect of kynurenic acid (KYNA) release on glutamatergic transmission in the hippocampus - a model of schizophrenia
K Jardemark, G Engberg, K Lindelöf, S Erhardt · 2026
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Description
K Jardemark and co-authors study a brain chemical in a model of schizophrenia in 2026. The chemical, kynurenic acid, affects glutamate signaling in the hippocampus. That area is thought to be overactive early in the illness.
Overactive glutamate flow may tip into cell damage over time. The chemical is made in the brain from a breakdown path of an amino acid. The team measured how its release changed signal flow between cells. Their model links a raised chemical level to faulty signaling. Readers learn how one small molecule may help explain psychosis, mood, and thinking problems in the illness.
Catalog record
| CREATOR | K Jardemark, G Engberg, K Lindelöf, S Erhardt |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |