808. Low-Dose Novel FLT3 Inhibitor Demonstrates Non-Opioid Analgesic Efficacy in Thermal and Inflammatory Pain Models
Y Moriya, R Saito-Moriya, Y Nago-Iwashita, I Sora, S A Maki, H Aoyama, K Ikeda · 2026
Read 808. Low-Dose Novel FLT3 Inhibitor Demonstrates Non-Opioid Analgesic Efficacy in Thermal and Inflammatory Pain Models by Y Moriya, R Saito-Moriya, Y Nago-Iwashita, I Sora, S A Maki, H Aoyama, K Ikeda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556657.txt.
Description
Moriya and co-authors test a new pain drug in rodents, built from a compound first made to treat a blood cancer. Pain care still leans on opioids, which carry a risk of dependence, and many chronic cases resist current drugs. The compound blocks a growth signal called FLT3, which may also act in the nervous system.
At a low dose, the drug eased pain in heat tests about an hour after dosing, and in a chemical pain test from half an hour on. It still worked in mice bred to lack the main opioid receptor, proof that its path is not the opioid one. The authors see it as a hopeful non-opioid route for pain care.
Catalog record
| CREATOR | Y Moriya, R Saito-Moriya, Y Nago-Iwashita, I Sora, S A Maki, H Aoyama, K Ikeda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |