826. Polygenic liability to psychiatric disorders predicts depressive and anxiety symptoms across pregnancy and postpartum
B Vai, L Fortaner-Uyà, M Shahisavandi, L Tian, J Tuhkanen, C Verga, I K Schuurmans, A Cattaneo, A Neumann, J Lahti, K Raikkonen, C Cecil, F Benedetti · 2026
Read 826. Polygenic liability to psychiatric disorders predicts depressive and anxiety symptoms across pregnancy and postpartum by B Vai, L Fortaner-Uyà, M Shahisavandi, L Tian, J Tuhkanen, C Verga, I K Schuurmans, A Cattaneo, A Neumann, J Lahti, K Raikkonen, C Cecil, F Benedetti (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556636.txt.
Description
Depression around childbirth strikes about seventeen percent of women and often goes unseen. Vai and co-authors ask in 2026 whether inherited liability, summed into polygenic risk scores, forecasts symptoms across pregnancy and the months after. They computed scores for twenty-four traits, psychiatric, metabolic, immune, and hormonal, in two cohorts totaling nearly six thousand mothers.
At twenty weeks of pregnancy, liability scores for depression, schizophrenia, and ADHD tracked depressive symptoms, and depression and ADHD scores tracked anxiety as well. Pooling both cohorts with careful bootstrapping kept the estimates honest. The work frames perinatal mood risk as partly written in the genome long before delivery.
Catalog record
| CREATOR | B Vai, L Fortaner-Uyà, M Shahisavandi, L Tian, J Tuhkanen, C Verga, I K Schuurmans, A Cattaneo, A Neumann, J Lahti, K Raikkonen, C Cecil, F Benedetti |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |