777. Advancing biological subtypes of treatment-resistant depression
K Dunlop · 2026
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Description
K Dunlop presents work on biological subtypes of treatment resistant depression in a 2026 conference abstract. Major depression varies widely between patients, yet diagnosis treats it as one condition. That mismatch has blocked the search for stable brain markers and biology based treatments.
The project combines symptom measures with resting brain connectivity data from 328 people with depression. A regularized method extracts shared dimensions between symptoms and brain patterns while guarding against overfitting. Cross checks test whether those dimensions hold in new samples. The author also asks whether the dimensions sort patients into subtypes with distinct brain profiles and treatment responses. The aim is a firmer base for personalized care, including brain stimulation choices.
Catalog record
| CREATOR | K Dunlop |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |