296. Intranasal administration of transforming growth factor beta 1 and its effect on the monoaminergic neurons in the rat brain
M Račický, R Paliokha, E Dremencov, D Grinchii · 2026
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Description
M Racicky and co-authors test a growth factor given through the nose in rats in 2026. The factor, TGF-beta 1, guides cell growth and survival. It is also tied to the lasting mood effect of arketamine.
Faulty signaling of the factor has been linked to thinking deficits in depression models. Nasal dosing offers a direct route toward the brain. The team measured effects on serotonin, dopamine, and noradrenaline neurons. Firing patterns of those cells were the main readout. Readers learn whether a nose-delivered factor can tune the very neurons that standard mood drugs target.
Catalog record
| CREATOR | M Račický, R Paliokha, E Dremencov, D Grinchii |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |