683. Genomic foundations of precision treatment: polygenic risk and pleiotropy in predicting therapeutic response
C Pisanu, Y Xiong, D Congiu, A Meloni, P Paribello, G Severino, M Del Zompo, Y Lu, M Manchia, A Squassina · 2026
Read 683. Genomic foundations of precision treatment: polygenic risk and pleiotropy in predicting therapeutic response by C Pisanu, Y Xiong, D Congiu, A Meloni, P Paribello, G Severino, M Del Zompo, Y Lu, M Manchia, A Squassina (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556557.txt.
Description
Pisanu and co-authors hunt genetic roots of treatment-resistant depression in this 2026 conference abstract. A third of patients with major depression resist standard treatment, yet few genetic determinants are known. The team applied cross-trait methods to large genome-wide datasets, conditioning on inflammation, metabolism, and aging markers.
Their scans found sets of variants tied to resistance under each lens, with three loci shared across all three. Two pointed to genes already linked to the condition, and several were new. A second method tied higher activity of one gene in brain tissue to resistance. Work conditioning on body weight and diabetes traits is ongoing. The authors argue shared biology across traits can expose hidden determinants of hard-to-treat depression.
Catalog record
| CREATOR | C Pisanu, Y Xiong, D Congiu, A Meloni, P Paribello, G Severino, M Del Zompo, Y Lu, M Manchia, A Squassina |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |