206. Adaptive immune system changes related to stress and depression: clinical and preclinical insights
S Kigar, X Shen, S White, X Liu, E Miska, E Bullmore, M-E Lynall · 2026
Read 206. Adaptive immune system changes related to stress and depression: clinical and preclinical insights by S Kigar, X Shen, S White, X Liu, E Miska, E Bullmore, M-E Lynall (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13556397.txt.
Description
S Kigar and co-authors review immune changes in stress and depression in 2026. Animal work showed that chronic social stress reshapes immune cells around the body and brain. Those shifts tracked depression-like behavior.
Human studies found that blood CD4 T cell levels predict depression status. Gene risk variants for depression cluster in control regions used by those cells. The authors argue that feedback to these T cells may drive progression. Both lab and clinic findings are drawn together. Readers learn why the adaptive immune system, not just inflammation in general, deserves focus in mood research.
Catalog record
| CREATOR | S Kigar, X Shen, S White, X Liu, E Miska, E Bullmore, M-E Lynall |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |