Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1
Étienne Bélanger, Alexandra Tauzin, Fitsumbrhan Tajebe, Monika Chandravanshi, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Catherine Bourassa, Halima Medjahed, William D. Tolbert, Madeleine Durand, Jonathan Richard, Donna M. Huryn, Simona Stäger, Marzena Pazgier, Andrés Finzi · 2026
Read Nef and Vpu protect infected cells from ADCP mediated by plasma from people with HIV-1 by Étienne Bélanger, Alexandra Tauzin, Fitsumbrhan Tajebe, Monika Chandravanshi, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Catherine Bourassa, Halima Medjahed, William D. Tolbert, Madeleine Durand, Jonathan Richard, Donna M. Huryn, Simona Stäger, Marzena Pazgier, Andrés Finzi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13556255.txt.
Description
Bélanger and colleagues showed in 2026 that two HIV proteins shield infected cells from being eaten by immune cells. Antibody-dependent cellular phagocytosis, or ADCP, is a process where antibodies flag infected cells for swallowing by scavenger cells. HIV's envelope protein is the only viral target on an infected cell's surface, but it usually stays in a closed shape that antibodies miss.
Deleting Nef and Vpu from HIV copies made infected cells vulnerable to swallowing when HIV-positive plasma was present. Small compounds that mimic CD4 forced the envelope open and likewise sensitised infected cells to ADCP. Boosting surface envelope through an interferon-driven protein raised the effect further. The authors argue ADCP can be harnessed alongside other antibody attacks to shrink the HIV reservoir.
Catalog record
| CREATOR | Étienne Bélanger, Alexandra Tauzin, Fitsumbrhan Tajebe, Monika Chandravanshi, Derek Yang, Hung-Ching Chen, Ta-Jung Chiu, Catherine Bourassa, Halima Medjahed, William D. Tolbert, Madeleine Durand, Jonathan Richard, Donna M. Huryn, Simona Stäger, Marzena Pazgier, Andrés Finzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |