Systematic Investigation on Particle and Pore Size Effects of Mesoporous Silica on Molecular Mobility and Physical Stability of Overloaded Amorphous Acetaminophen
Francisca Larasati, Kohsaku Kawakami · 2026
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Description
Francisca Larasati and Kohsaku Kawakami study how silica carriers steady a common drug in a 2026 paper. Drugs in glassy, non crystal form dissolve faster but can revert over time. Porous silica can hold such drugs and slow the reversion. The pair varied the silica pore and grain sizes to map the effect.
Heat scans split the drug into free, middle, and rigid portions. The free part behaved like the pure glassy drug alone. Wide pores let the steadier middle part take over at high silica shares. Narrow pores left much of the free part in place instead.
Catalog record
| CREATOR | Francisca Larasati, Kohsaku Kawakami |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |