Michael addition-based synthesis of lawsone-derived benzopyrans: antibacterial, CREST and ADMET studies
Ananya Dash, Barsha Samanta, Sonali Priyadarshini Parida, Tapaswini Pati, Laxmipriya Dash, Bhabani Shankar Panda, Chita Ranjan Sahoo, Seetaram Mohapatra · 2026
Read Michael addition-based synthesis of lawsone-derived benzopyrans: antibacterial, CREST and ADMET studies by Ananya Dash, Barsha Samanta, Sonali Priyadarshini Parida, Tapaswini Pati, Laxmipriya Dash, Bhabani Shankar Panda, Chita Ranjan Sahoo, Seetaram Mohapatra (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13555912.txt.
Description
Ananya Dash and co-authors make a new family of bacteria-fighting compounds from a plant dye, in a chemistry paper from 2026. The starting material is lawsone, the dye in henna, joined to other parts through a Michael addition reaction. The products are highly substituted benzopyrans made at room temperature.
Yields ran from 62 to 94 percent, and spectra confirmed each structure. Computer shape searches pinned down the lowest-energy form of the key scaffold. In dish tests, one compound stood out against two major bacteria, blocking growth at low doses. Docking studies showed it binds the bacterial enzyme DNA gyrase tightly. Drug-likeness checks rated the family well, and the authors propose them as leads for new antibiotics.
Catalog record
| CREATOR | Ananya Dash, Barsha Samanta, Sonali Priyadarshini Parida, Tapaswini Pati, Laxmipriya Dash, Bhabani Shankar Panda, Chita Ranjan Sahoo, Seetaram Mohapatra |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 64 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |