Redefining early stage nonsmall cell lung cancer: The dawn of the risk‐adaptive and biologically precise era

Clarissa Mathias, Fabio Ynoe Moraes · 2026

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Description

Clarissa Mathias and Fabio Moraes argue that early lung cancer care is shifting from size charts to biology, in a 2026 commentary. For decades, early non-small cell lung cancer was staged by anatomy and treated mainly with surgery. That simple scheme helped many patients but ignores how differently tumors behave.

Screening advances, gentler surgery, precise radiation, gene profiling, and drug therapy around surgery have changed the field together. Care can now adapt to a tumor’s recurrence risk and molecular traits, not just its size and spread. Discussing a recent review by Zhang and colleagues, the authors map the new era of risk-adaptive, biologically precise care. Patients with the same stage may rightly receive quite different plans.

Catalog record

CREATORClarissa Mathias, Fabio Ynoe Moraes
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE12 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13555831

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