More efficient screening for preclinical Alzheimer's clinical trials using mixture of experts
Oliver Langford, Rema Raman, Paul Aisen, Reisa Sperling, Keith Johnson, Doris Molina‐Henry, Pallavi Sachdev, David Li, Gustavo A. Jimenez‐Maggiora, Sterling C. Johnson, Joel B Braunstein, Colin Birkenbihl, Madison Cuppels, Rachel F. Buckley, Robert A. Rissman, Michael C. Donohue · 2026
Read More efficient screening for preclinical Alzheimer's clinical trials using mixture of experts by Oliver Langford, Rema Raman, Paul Aisen, Reisa Sperling, Keith Johnson, Doris Molina‐Henry, Pallavi Sachdev, David Li, Gustavo A. Jimenez‐Maggiora, Sterling C. Johnson, Joel B Braunstein, Colin Birkenbihl, Madison Cuppels, Rachel F. Buckley, Robert A. Rissman, Michael C. Donohue (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13555808.txt.
Description
Trials of Alzheimer's drugs before symptoms begin must screen huge numbers of healthy older adults, and most fail the brain scan test. Oliver Langford and co-authors report in 2026 on a blood-based screen used in one such trial of the drug lecanemab. A mixture-of-experts model estimated each volunteer's chance of amyloid buildup from blood markers.
Adding the markers in stages cut scan ineligibility from seventy-one percent to thirty-one percent. The model also sorted people into low, middle, and high amyloid groups, with one marker best spotting the high group and another best clearing the low. The authors say blood screening eased the burden on volunteers and sites while keeping the trial enriched for the target pathology.
Catalog record
| CREATOR | Oliver Langford, Rema Raman, Paul Aisen, Reisa Sperling, Keith Johnson, Doris Molina‐Henry, Pallavi Sachdev, David Li, Gustavo A. Jimenez‐Maggiora, Sterling C. Johnson, Joel B Braunstein, Colin Birkenbihl, Madison Cuppels, Rachel F. Buckley, Robert A. Rissman, Michael C. Donohue |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |