Stimuli-responsive nanozyme-hydrogel systems for ischemic stroke: toward spatiotemporal catalytic control of the neurovascular unit
Sen Yan, Xiaohong Wang, Cai Li, Rong Wang · 2026
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Description
Sen Yan, Xiaohong Wang, Cai Li, and Rong Wang review smart gel systems for stroke treatment in a paper from 2026. Ischemic stroke unfolds in fast-changing phases, from oxygen burst to inflammation to repair. Single-dose protectants match that timeline poorly. The review examines hydrogels loaded with nanozymes, tiny catalytic particles, that switch on under local cues. Cues include acidity, low oxygen, clotting enzymes, and inflammatory signals.
Designs vary in how particles are trapped, anchored, or assembled in place. The goal is phase-matched care of the vessel and brain tissue together. Direct evidence for full systems in stroke remains thin, the authors admit. They propose benchmarks for testing before any clinical claims. The piece is a design framework, not a readiness report.
Catalog record
| CREATOR | Sen Yan, Xiaohong Wang, Cai Li, Rong Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |